This medicine is not recommended for use in children. Goldfrank's toxicologic emergencies(Tenth ed.). Symptoms of hypercalcemia include lethargy, nausea, vomiting or coma. Caution in patients receiving digoxin concomitantly. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Bailey, B., Blais, R., Gaudreault, P., Gosselin, S., & Laliberte, M. (2009). Micromedex health care systems. pH (range 5.5-7.5) adjusted with Hydrochloric Acid and/or Sodium Hydroxide. (2014). -This product contains aluminum, which may become toxic with prolonged parenteral administration in patients with impaired renal function. -Premature neonates are at increased risk for aluminum toxicity due to their immature kidneys and need for large calcium and phosphate doses, which contain aluminum. Haddad and Winchester's clinical management of poisoning and drug overdose (Fourth ed.). Phelps SJ, C. C. (2013). Reconstitution/preparation techniques: Ionized calcium may also be measured. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. (Ed. Retrieved from http://www.pharmpress.com/product/MC_PED/pediatric-injectable-drugs. New York: McGraw Hill. Walter F. G. DESCRIPTION Each mL contains: 100 mg calcium chloride (calcium chloride) dihydrate in water for injection q.s. -Observe for signs of recovery before administering additional doses. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. (2014). Bailey, B., Blais, R., Gaudreault, P., Gosselin, S., & Laliberte, M. (2009). Goldfrank, L. R., Nelson, L. S., Lewin, N. A., Howland, M. A., Hoffman, R. S., (2015). Maximum pediatric dose: 1 g (1000mg) or 10 mL of 10% calcium chloride IV direct. Use: Hypocalcemia in conditions requiring prompt blood calcium increases, Initial dose: 500 mg by slow intravenous injection Maximum rate: 1 mL/min (2013). Micromedex, T. H. A. Calcium chloride should be given with extreme caution, and in reduced dosage, to persons taking digitalis because it increases ventricular irritability and may precipitate digitalis toxicity. 500 to 1000 mg by slow intravenous injection Adults in acute hypocalcaemia, a typical dose is 2.25 to 4.5 mmol (approximately 3-7ml of a 10% w/v solution) of calcium given by slow intravenous infusion and repeated as required. -Patients, including premature neonates, with impaired kidney function who receive over 4 to 5 mcg/kg/day aluminum have accumulation levels associated with central nervous system and bone toxicity; tissue loading may occur at lower administration rates also. Sweating, tingling sensations, “heat waves”, tissue irritation and necrosis. IWK Regional Poison Centre. Data not available Repeat every 10 - 20 minutes as required; after four doses, monitor serum calcium levels and reassess. (Ed.). Flushing, nausea, vomiting, drowsiness, hypotension and chalky or metallic taste. (2014). Calcium chloride should not be administered in the same infusion with sodium bicarbonate, since calcium will combine with sodium bicarbonate to form an insoluble precipitate (calcium carbonate). Not for intramuscular use, or subcutaneous use . -The patient should remain recumbent for a short time after the infusion. Retrieved from http://www.micromedexsolutions.com. Maximum rate: 1 mL/min (3rd ed.). (17th ed.). Repeat every 10 - 20 minutes as required; after four doses, monitor serum calcium levels and reassess. Tucson, Arizona: The University of Arizona College of Medicine. Acute oral toxicity of calcium chloride is low, as evidenced by the studies with rats administered single doses of calcium chloride dissolved in water or in 5% Arabic gum, resulting in LD50 > 2000 mg/kg bw. -This drug must not be injected into the myocardial tissue; only inject into the ventricular cavity during cardiac resuscitation. 10% calcium chloride injection is a sterile, nonpyrogenic, hypertonic solution. Bethesda, Maryland: American Society of Health-System Pharmacists. In hypoalbuminemic patients, the corrected total serum calcium can be estimated with the formula: corrected calcium (mmol/L) = total measured calcium (mmol/L) +[0.02 x {40-albumin (g/L)}]. Calcium channel blocker toxicity: Infants, Children, and Adolescents: Dosage expressed in mg of calcium chloride: IV: 20 mg/kg/dose infused over 5 to 10 minutes; if effective, consider IV infusion of 20 to 50 mg/kg/hour (Kleinman 2010). ), AHLS advanced hazmat life support, provider manual (4th ed.). Poisoning & drug overdose (Sixth ed.). Applies to the following strengths: 100 mg/mL, Usual dose: 500 to 1000 mg by slow intravenous injection, every 1 to 3 days depending on response and/or serum calcium OR Consult WARNINGS section for additional precautions. Rapid IV administration may cause vasodilation, hypotension, bradycardia, cardiac arrhythmia, syncope and cardiac arrest. Use: Magnesium toxicity due to magnesium sulfate overdose, Dose is titrated by constant ECG monitoring Rapid IV administration may cause bradycardia or asystole. Maximum rate: 1 mL/min Method of administration. IV calcium can be given as 10 mL of a 10% calcium gluconate solution over 2 to 3 minutes or as calcium chloride, which contains three times the amount of calcium per 10 mL dose. (2014). Select one or more newsletters to continue. Unpublished manuscript. Prendre une seule dose de Calcium Chloride expiré est peu susceptible de produire un événement indésirable. Each mL contains 100 mg (1.4 mEq/mL) of calcium chloride, dihydrate (1.4 mEq each of Ca ++ and Cl −) in water for injection.It is provided in a 10 mL single-dose vial to facilitate prompt intravenous injection. Micromedex health care systems. IWK Regional Poison Centre 1.800.565.8161 | www.IWKPoisonCentre.caLast updated: 02/2020. -Use great care to avoid extravasation or perivascular injection. -Inspect for particulates and discoloration. Micromedex, T. H. A. (2011). We comply with the HONcode standard for trustworthy health information -. Teddy bear, pediatric injectable drugs. Shannon, M. W., Borron, S. W., & Burns, M. J.
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