This is a bigger risk for anyone with current liver problems or liver damage, a history of liver problems, and people with underlying conditions including cancer and HIV. https://www.rxlist.com/diflucan-side-effects-drug-center.htm For other infections, your first dose may be a double dose. Rare cases of seizures have been reported, but a causal relationship was difficult to establish, since some of these patients had cryptococcal meningitis or severe underlying disease. Fluconazole oral tablet is obtainable as both a generic and a brand-name drug. You may take fluconazole with or without food. Typical dosage: Dosage depends on the weight of the child taking the drug, and the type of infection being treated. Fluconazole is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood. You may report side effects to FDA at 1-800-FDA-1088. This medication shouldn’t be stored in moist or damp areas, such as bathrooms. Learn about side effects, drug interactions, dosages, warnings, and more. N Engl J Med 326 (1992): 83-9, 6. This drug was generally well tolerated. For the Consumer. Fluconazole side effects must be carefully weighed and balanced against its benefits before patients and their doctors decide to use it. What is the dose of fluconazole for tinea? The spectrum of these hepatic reactions has ranged from mild transient elevations in transaminases to clinical hepatitis, cholestasis and fulminant hepatic failure, including fatalities. J Am Acad Dermatol 35 (1996): 284, 37. Roerig Division, New York, NY. Always carry your medication at all times. Treatment was discontinued in 2.3% of patients due to adverse clinical events and in 1.4% of patients due to laboratory test abnormalities. Our website services, content, and products are for informational purposes only. You may report them to the FDA. A nursing mother should consult a doctor before taking these drugs, As she may need to decide whether to stop breastfeeding or stop taking this drug. Serum transaminase elevations (greater than 8 times the upper limit of normal [8 x ULN]; about 1%) and statistically significant increases in AST have been reported. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Fluconazole isn’t known to cause drowsiness, but it can cause other side effects. Fluconazole may cause liver cell death, hepatitis, jaundice, and liver failure. Five months after the initial presentation, the patient returned with reports of increasing pedal edema. N Engl J Med 326 (1992): 845-51, 15. The liquid form of fluconazole contains sucrose. It works by preventing the fungi that are causing infection from reproducing and the infection from continuing. The latter condition is ultimately fatal if not treated. Read the entire detailed patient monograph for Diflucan (Fluconazole). See additional information. A 58-year-old female with a history of hypertension and cervical cancer experienced membranous nephropathy coincident with this drug. Some medicines can cause unwanted or dangerous effects when used with fluconazole. These include vaginal, abdominal, esophageal, lung, blood, and mouth yeast infections. Common side effects include: Diarrhea; Headache; Stomach pain; Vomiting; Severe rash (more common in people with a weakened immune system); In rare cases, fluconazole can cause serious liver damage. Diagn Microbiol Infect Dis 12 (1989): s239-47, 14. Although this drug has been well tolerated by many and brought comfort and relief from infections, there is a long and troubling list of fluconazole side effects that cause too many people to suffer unnecessarily. Your email address will not be published. The patient presented with increasing generalized edema accompanied by nausea and indigestion for 3 weeks. QT prolongation and torsade de pointes have also been reported during postmarketing experience. Hematopoietic and Lymphatic: Leukopenia, including neutropenia and agranulocytosis, thrombocytopenia. Grant SM, Clissold SP "Fluconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses." Taking Theophylline drug with fluconazole can cause headaches, seizures, low blood pressure, and muscle cramps. Symptoms can include: This drug shouldn’t be taken if one has suffered an allergic reaction to it previously, as retaking it could be fatal ( and can cause death even). People who have undergone bone marrow transplants may be treated with fluconazole to prevent future occurrence of candidiasis. These drugs treat and cure fungal infections by acting on an enzyme on fungal cells. In each of these cases, liver function returned to baseline on discontinuation of DIFLUCAN. In some patients, particularly those with serious underlying diseases such as AIDS and cancer, changes in renal and hematological function test results and hepatic abnormalities have been observed during treatment with fluconazole and comparative agents, but the clinical significance and relationship to treatment is uncertain. Store fluconazole at room temperature away from moisture and heat. Am J Kidney Dis 49 (2007): 318-22. It also comes in an injectable form that can only be administered by a healthcare provider. Arch Intern Med 151 (1991): 1020-1, 21. Fluconazole side effects (in more detail). Plaintiffs are expected to file soon and if you were impacted by the side effects of fluconazole you could be involved. Fluconazole may also be used for purposes not listed in this medication guide. Skin and Appendages: Acute generalized exanthematous pustulosis, drug eruption including fixed drug eruption, increased sweating, exfoliative skin disorders including Stevens-Johnson syndrome and toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS) (see WARNINGS), alopecia. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to fluconazole: intravenous solution, oral powder for reconstitution, oral tablet. Treatment length: The length of treatment depends on the infection being treated. Over the subsequent 36-hours, the patient remained in sinus rhythm except for one brief run of ventricular bigeminy. Along with its needed effects, fluconazole may cause some unwanted effects. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A severe allergic reaction is a possible side effect for some patients. Skipping doses can increase your risk of infection that is resistant to medication. One should not need a new prescription for this medication to be refilled. But if one remembers just a few hours before the next scheduled dose, take only one treatment, although they shouldn’t try to catch up by taking two doses at once. Wells C, Lever AM "Dose-dependent fluconazole hepatotoxicity proven on biopsy and rechallenge ." Vincent-Ballereau FN, Patey ON, Lafaix C "Fluconazole: review and situation among antifungal drugs in the treatment of opportunistic mycoses of human immuno-deficiency virus infections." Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Therapy was started with fluconazole 150 mg IV every 12 hours. Signs of anaphylaxis include itchy skin and hives, swelling in the face, mouth, and throat, and difficulty breathing. Persons who have certain conditions that lower body immunity, such as cancer, human immunodeficiency virus infection (HIV), or acquired immunodeficiency syndrome (AIDS), are very likely to get a rash from fluconazole. Guillaume MP, Deprez C, Cogan E "Subacute mitochondrial liver disease in a patient with AIDS: possible relationship to prolonged fluconazole administration." Goodman JL, Winston DJ, Greenfield RA, et al "A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation." Clinical findings showed the patient had stage I membranous nephropathy. The agency got the information out to the public, but stated that it would spend more time going over the results of the study and doing its own analysis before making a decision about what to do next. At initial presentation, the patient's medication history included amlodipine, hydrochlorothiazide, metoclopramide, and levosulpiride. Not all possible interactions are listed here. This drug works by preventing the fungi Candida and Cryptococcus to reproduce. In combined clinical trials and marketing experience, there have been rare cases of serious hepatic reactions during treatment with DIFLUCAN. 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